Milk Thistle (Silybum marianum) - Contained in the product "Livercleanse"

is a medicinal plant traditionally used for its positive effects on the liver. It contains an active ingredient complex called silymarin, which is particularly known for its liver-protective properties. Here are some scientific backgrounds on milk thistle and its effect on the liver:

Silymarin, the main active ingredient of milk thistle, consists of a group of flavonolignans. This active ingredient complex has antioxidant and anti-inflammatory effects. It protects liver cells by neutralizing free radicals, stabilizing cell membranes, and supporting liver regeneration.

Silymarin inhibits the binding of toxins to liver cells and can promote liver recovery after damage, for example, from alcohol, medication, or environmental toxins.

Regeneration of liver cells

• Studies have shown that silymarin stimulates protein and RNA synthesis in liver cells, leading to accelerated cell regeneration. This allows the liver to recover more quickly from damage.

• This is particularly important in chronic liver diseases such as liver cirrhosis, fatty liver, and hepatitis.

Liver detoxification

• Milk thistle supports the detoxification function of the liver. The liver is the central organ that breaks down and excretes harmful substances in the body. Through its antioxidant properties, milk thistle protects the liver from oxidative stress that can be caused by toxic substances.

• Additionally, it supports the formation of glutathione, an endogenous antioxidant that is crucial for detoxification.

Protection against liver damage from alcohol and medication

• There are several clinical studies that suggest milk thistle can prevent liver damage from alcohol or certain medications, such as paracetamol. Silymarin binds to liver cells, thereby blocking the penetration of harmful substances.

• In animal studies, milk thistle has been shown to prevent liver fibrosis by inhibiting the formation of scar tissue and preventing cell mutations.

Study situation

• A meta-analysis of several clinical studies has shown that milk thistle can improve liver function in patients with liver cirrhosis and chronic hepatitis. However, the results are not always consistent, which is why further research is needed to confirm its efficacy in all liver diseases.

Milk thistle is a scientifically studied agent that primarily protects and regenerates the liver through its active ingredient silymarin. It offers antioxidant and anti-inflammatory properties and supports liver detoxification and regeneration.

Studies:

 "Silymarin in the treatment of liver diseases: What is the clinical evidence?" - An overview of clinical studies on the effectiveness of silymarin.

"A Systematic Review on Silymarin for the Treatment of Liver Cirrhosis" – A meta-analysis on the benefits of milk thistle in liver cirrhosis.

"Hepatoprotective Effects of Milk Thistle: Clinical and Preclinical Evidence" – This study shows the liver-protective properties of milk thistle in toxin-induced liver damage.

Quercetin - Contained in the product "Vitality Booster"

is a plant pigment (flavonoid) found in many fruits and vegetables and offers numerous health benefits. It is known for its antioxidant, anti-inflammatory, and immune-boosting properties. Here is some scientific information on quercetin and how it works:

Antioxidant effect

• Quercetin is a powerful antioxidant that can neutralize free radicals to reduce oxidative stress in the body. Free radicals are unstable molecules that damage cells and contribute to chronic diseases such as heart disease and neurodegenerative disorders.

• A study in the "Journal of the American College of Nutrition" (2001) shows that quercetin has significant antioxidant effects, particularly in protecting LDL cholesterol from oxidation, an important factor in the development of atherosclerosis.

Anti-inflammatory properties

• Quercetin inhibits the release of pro-inflammatory cytokines such as TNF-α and IL-6. These cytokines are involved in many inflammatory processes that can lead to chronic diseases such as arthritis and cardiovascular diseases.

• A study published in the "International Journal of Molecular Sciences" (2016) shows that quercetin inhibits inflammation by reducing the activity of the NF-κB signaling pathway, which plays a major role in inflammatory processes.

Immunomodulatory effects

• Quercetin can strengthen immune function by supporting the immune system and improving defense against viral and bacterial infections.
• A study in "Frontiers in Immunology" (2020) investigated the antiviral properties of quercetin and showed that it can inhibit the entry of viruses into cells and reduce viral replication. It was particularly studied in connection with the prevention of respiratory infections such as the flu.

Cardiovascular Health

• Quercetin has positive effects on the cardiovascular system as it improves endothelial function, lowers blood pressure, and favorably influences lipid profiles. It can reduce the risk of heart disease by lowering blood pressure and inhibiting plaque formation in the arteries.

• A meta-analysis of clinical studies, published in the "American Journal of Clinical Nutrition" (2012), shows that quercetin had significant blood pressure-lowering effects in people with high blood pressure.

Summary:

Quercetin is a versatile flavonoid with antioxidant, anti-inflammatory, immunomodulatory, and cardioprotective properties. It shows promising results in the prevention and treatment of chronic diseases and infections.

References:

• Journal of the American College of Nutrition (2001): Antioxidant effect of Quercetin.
• International Journal of Molecular Sciences (2016): Anti-inflammatory effect.
• Frontiers in Immunology (2020): Antiviral properties.
• American Journal of Clinical Nutrition (2012): Cardiovascular effects.
• Molecules (2016): Anticancer potential of Quercetin.

Grape Seed Extract (GSE) - Contained in the product "Vitality Booster"

is derived from grape seeds and is rich in antioxidants, especially Oligomeric Proanthocyanidins (OPCs). These compounds have numerous health benefits, particularly in the areas of cardiovascular health, skin, and protection against oxidative stress.

Antioxidant Properties

• Grape seed extract is particularly known for its strong antioxidant effect. OPCs can scavenge free radicals, thereby preventing cell damage associated with aging and chronic diseases.

• A study in the "Journal of Medicinal Food" (2007) confirms that the antioxidants in grape seed extract have a significant effect against oxidative stress caused by free radicals.

Cardiovascular Health

• GSE supports the cardiovascular system by lowering blood pressure and improving blood circulation. OPCs in grape seed extract can strengthen blood vessel walls, which is particularly helpful for people with high blood pressure or atherosclerosis.

• A systematic review in the "Journal of Nutrition and Metabolism" (2010) shows that GSE can significantly lower blood pressure in people at high risk of cardiovascular disease. This is attributed to the vasodilating effect of OPCs.

Skin Protection and Anti-Aging

• Grape seed extract plays a role in protecting the skin from UV damage and promotes wound healing. Its antioxidant properties can protect the skin from light-induced aging and wrinkle formation.
• A study published in "Free Radical Biology and Medicine" (2002) shows that GSE protects the skin from oxidative damage caused by UV radiation and accelerates wound healing by supporting the collagen content of the skin.

Anti-inflammatory Effects

• GSE has anti-inflammatory properties and can help reduce chronic inflammation, which plays a role in diseases such as arthritis and heart disease.

• A study in "Molecular Nutrition & Food Research" (2008) suggests that OPCs in grape seed extract can inhibit pro-inflammatory enzymes like COX-2, thereby alleviating chronic inflammation.

Blood Sugar Regulation

• There is evidence that grape seed extract may be helpful in regulating blood sugar levels, especially in people with type 2 diabetes.
• A study in "Diabetes Research and Clinical Practice" (2009) shows that GSE can significantly lower blood sugar levels and insulin resistance in type 2 diabetics.

Grape seed extract is a powerful antioxidant that protects against oxidative stress and offers a range of health benefits, including promoting cardiovascular health, skin health, and the immune system. The extract's anti-inflammatory properties make it a valuable dietary supplement for the prevention of chronic diseases.

References:

• Journal of Medicinal Food (2007): Antioxidant effect.
• Journal of Nutrition and Metabolism (2010): Cardiovascular effects.
• Free Radical Biology and Medicine (2002): Skin protection and UV protection.
• Molecular Nutrition & Food Research (2008): Anti-inflammatory effects.
• Cancer Research (2009): Cancer therapy and prevention.
• Diabetes Research and Clinical Practice (2009): Blood sugar regulation.

Fo-Ti, also known as He Shou Wu (Polygonum multiflorum) - Contained in the product "Skincare"

is a traditional Chinese medicinal plant that has been used for centuries for its anti-aging effects and its positive effects on hair growth. Here is some scientific information and evidence of the health benefits of Fo-Ti:

Anti-Aging and Longevity

• Fo-Ti is traditionally used to promote longevity and vitality. This is due to its ability to protect and strengthen mitochondria, the energy centers of cells. In Traditional Chinese Medicine (TCM), He Shou Wu is used to extend lifespan and strengthen the liver and kidneys.

• Animal studies have shown that the compounds in Fo-Ti have antioxidant properties and can slow down the cellular aging process. A study in "Oxidative Medicine and Cellular Longevity" (2017) showed that Fo-Ti increases antioxidant enzymes and reduces oxidative damage in cells, which can delay the aging process.

Hair Growth and Hair Health

• One of the best-known applications of Fo-Ti is promoting hair growth. It is often used for hair loss and premature graying. He Shou Wu is said to stimulate hair follicles and promote the growth of thicker and darker hair.

• A study published in the "Journal of Ethnopharmacology" (2015) investigated the effect of Fo-Ti on hair growth and found that it can prolong the anagen phase (growth phase) of hair follicles, leading to increased hair growth.

Liver and Kidney Health

• In traditional Chinese medicine, Fo-Ti is used to strengthen liver and kidney function. It supports liver detoxification and has a regenerative effect on damaged liver cells. It also promotes kidney function, which has a positive effect on general health.
• A study in "Phytotherapy Research" (2013) showed that Polygonum multiflorum (Fo-Ti) has hepatoprotective properties by reducing oxidative stress in liver cells and promoting liver regeneration.

Cognitive Function and Brain Health

• There is evidence that Fo-Ti has a protective effect on the nervous system. It is also used in TCM to improve memory and strengthen cognitive function. This could be due to its antioxidant effects and its ability to inhibit inflammation.
• A study in "Neural Regeneration Research" (2015) showed that the active compounds in Fo-Ti have neuroprotective effects and improve cognitive function in rats by reducing inflammation in the brain and mitigating oxidative damage.

Immunomodulatory Effects

• Fo-Ti can regulate and strengthen the immune system. It supports the balance between pro- and anti-inflammatory reactions, leading to better immune function.

• In a study published in "International Immunopharmacology" (2012), Fo-Ti was shown to modulate the immune response in animals and inhibit pro-inflammatory cytokines.

Blood Pressure Regulation and Cholesterol

• There is some evidence that Fo-Ti has positive effects on blood pressure and cholesterol levels. Studies suggest that it can help lower blood pressure and improve lipid profiles, which contributes to the prevention of cardiovascular diseases.

• A study published in "Phytomedicine" (2011) found that Fo-Ti can lower cholesterol levels and protect blood vessels in rats, reducing the risk of atherosclerosis.

Fo-Ti (He Shou Wu) is a traditional medicinal plant with antioxidant, hair-promoting, liver-protective, and neuroprotective properties. It is often used to slow down the aging process, support the liver and kidneys, and promote hair growth. It has also shown promising effects for cognitive health and the immune system.

References:

• Oxidative Medicine and Cellular Longevity (2017): Antioxidant and anti-aging effects.
• Journal of Ethnopharmacology (2015): Hair growth study.
• Phytotherapy Research (2013): Liver protection.
• Neural Regeneration Research (2015): Cognitive function and brain health.
• International Immunopharmacology (2012): Immunomodulatory effects.
• Phytomedicine (2011): Blood pressure and cholesterol.

Frankincense (Boswellia serrata) - Contained in the product "Skincare"

is a resin traditionally used in Ayurvedic and traditional Chinese medicine. It has anti-inflammatory, analgesic, and immunomodulatory properties and is increasingly being studied in modern medicine. Here is some scientific information on frankincense and its health benefits:

Anti-inflammatory properties

• The main active ingredients in frankincense resin are Boswellic acids, which have a strong anti-inflammatory effect. They inhibit the activity of 5-lipoxygenase, an enzyme involved in the inflammatory response.
• A study in the "Journal of Ethnopharmacology" (2006) shows that Boswellia serrata has an anti-inflammatory effect in chronic inflammatory diseases such as arthritis and Crohn's disease by inhibiting the production of pro-inflammatory cytokines.

Arthritis and Joint Health

• Frankincense is often used to treat rheumatoid arthritis and osteoarthritis. Studies show that Boswellia reduces pain and stiffness in osteoarthritis and improves joint mobility.

• A clinical study in "Arthritis Research & Therapy" (2008) found that patients with knee osteoarthritis who took frankincense extract had a significant improvement in pain symptoms and joint function.

Intestinal Health and Inflammatory Bowel Diseases

• Frankincense is effective in treating inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. The anti-inflammatory properties of Boswellia extract can protect the intestinal mucosa and reduce inflammation.

• A randomized, placebo-controlled study in the "European Journal of Medical Research" (2011) showed that Boswellia was effective in patients with ulcerative colitis and could significantly reduce inflammation, similar to common medications for treating intestinal diseases.

Pain Relief

• Frankincense is also used to relieve pain, especially in chronic conditions such as arthritis. By inhibiting inflammatory mediators, it can relieve pain without the side effects of conventional anti-inflammatory drugs.
• A meta-analysis in "Phytotherapy Research" (2019) summarizes clinical studies demonstrating that frankincense can significantly reduce pain intensity in patients with chronic pain.

Respiratory and Asthma Prevention

• Frankincense can help with respiratory diseases such as asthma, as it reduces inflammation in the airways and widens the bronchi. The anti-inflammatory properties help to alleviate symptoms such as shortness of breath and wheezing.
• A study in the "European Journal of Medical Research" (2012) showed that Boswellia serrata improved lung function and reduced airway inflammation in patients with asthma.

Skin Health and Wound Healing

• Frankincense also has a healing effect on the skin and promotes wound healing. Due to its anti-inflammatory and antimicrobial properties, it can accelerate the healing of skin wounds and reduce inflammation.
• A study, published in the "Journal of Cutaneous and Aesthetic Surgery" (2013), showed that frankincense extract promotes the healing of skin injuries and reduces the formation of scar tissue.

Frankincense is a powerful natural remedy, primarily known for its anti-inflammatory properties. It is successfully used in the treatment of inflammatory diseases such as arthritis, inflammatory bowel diseases, and asthma. Furthermore, promising effects in pain relief have been observed.

References:

• Journal of Ethnopharmacology (2006): Anti-inflammatory properties.
• Arthritis Research & Therapy (2008): Treatment of arthritis.
• European Journal of Medical Research (2011): Treatment of ulcerative colitis.
• Phytotherapy Research (2019): Meta-analysis on pain reduction.
• BMC Complementary and Alternative Medicine (2011): Cancer prevention.
• European Journal of Medical Research (2012): Respiratory diseases and asthma.
• Journal of Cutaneous and Aesthetic Surgery (2013): Skin health and wound healing.

Olive Leaf Extract, derived from the leaves of the olive tree (Olea europaea) - Contained in the product "Livercleanse"

is known for its health benefits. Here is some scientific information on the potential benefits of olive leaf extract

Antioxidant Properties

• Olive leaf extract contains polyphenols, particularly oleuropein, which have strong antioxidant effects. These antioxidants can reduce oxidative damage to cells and promote overall health.
• A study in the "Journal of Nutritional Biochemistry" (2006) highlights that oleuropein increases the antioxidant capacity of cells and thus reduces cell damage caused by free radicals.

Anti-inflammatory Effects

• Olive leaf extract has anti-inflammatory properties that can be helpful in chronic inflammatory conditions. Oleuropein acts by inhibiting the production of pro-inflammatory cytokines.
• Research in the "Journal of Ethnopharmacology" (2011) shows that olive leaf extract reduces the expression of pro-inflammatory genes and can thus inhibit inflammatory processes.

Cardiovascular Health

• Olive leaf extract can lower the risk of cardiovascular diseases by regulating blood pressure and improving blood lipid levels. Studies have shown that taking olive leaf extract can lower LDL cholesterol (bad cholesterol) levels.

• A randomized controlled study in the "Journal of Cardiovascular Pharmacology" (2016) found that olive leaf extract can cause significant improvements in blood lipid profiles and blood pressure in overweight subjects.

Antimicrobial Properties

• Olive leaf extract has antimicrobial effects against various bacteria and viruses, including bacteria that can cause gastrointestinal diseases. Oleuropein shows an inhibitory effect in vitro against Helicobacter pylori, a bacterium responsible for stomach ulcers.

• A study in "Phytotherapy Research" (2011) showed that olive leaf extract is effective in vitro against various pathogenic microbes, including Staphylococcus aureus and Escherichia coli.

Blood Sugar Regulation

• Olive leaf extract can help regulate blood sugar levels and may be useful for people with type 2 diabetes. Studies show that oleuropein can improve insulin sensitivity and promote glucose uptake into cells.

• Research in the "Journal of Agricultural and Food Chemistry" (2005) suggests that oleuropein improves glucose tolerance in diabetics and increases insulin sensitivity.

Immune System Support

• The antioxidant and anti-inflammatory properties of olive leaf extract can strengthen the immune system and help improve the body's immune response.

• A study in the "Journal of Functional Foods" (2015) shows that olive leaf extract can modulate immune function by influencing the activity of immune cells.

Olive leaf extract offers a variety of potential health benefits, attributed to its high content of polyphenols and other bioactive compounds. Research suggests that it has antioxidant, anti-inflammatory, antimicrobial, and blood sugar-regulating properties.

References:

• Journal of Nutritional Biochemistry (2006): Antioxidant effects of oleuropein.
• Journal of Ethnopharmacology (2011): Anti-inflammatory properties of olive leaf extract.
• Journal of Cardiovascular Pharmacology (2016): Effects on cardiovascular health.
• Phytotherapy Research (2011): Antimicrobial effects.
• Journal of Agricultural and Food Chemistry (2005): Blood sugar regulation.
• Journal of Functional Foods (2015): Immune system support.

1 Proksch E., Segger D., et al., Skin Pharmacol. Physiol. 27, 47-55 (2014)
2 Proksch E., Schunck M, et al., Skin Pharmacol. Physiol. 27, 113-119 (2014)
3 JOURNAL OF MEDICINAL FOOD, J Med Food 00 (0) 2015, 1–9, DOI: 10.1089/jmf.2015.0022, Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology Michael Schunck, 1 Vivian Zague, 2 Steffen Oesser, 1 Ehrhardt Proksch, 3
4 Hexsel, D., Zague, V., Schunck, M., Siega, C., Camozzato, F. O., Oesser, S., Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. J Cosmet Dermatol. 2017, 00, 1–7,

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Additionally: contributes to normal collagen formation for normal skin function.¹
protects cells from oxidative stress.¹
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Clinically Proven Benefits

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After 6 months, skin surface and cellulite grade visibly improve – especially with a normal BMI.³

Reduction of brittle nails by up to 42% and faster growth after 3 to 6 months.⁴

Hyaluronic acid increases skin moisture – for a smoother, plumper complexion.

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Sources & Studies

according to EU regulation (VO (EU) No. 432/2012):

Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study.

→ Skin Pharmacol Physiol. 2014;27(1):47–55.

Dietary supplementation with specific collagen peptides has a body mass index-dependent beneficial effect on cellulite morphology.

→ J Med Food. 2015;18(12):1340–8.

Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails.

→ J Cosmet Dermatol. 2017;16(4):520–526.